Fig. 1 · Structure
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Valiglurax
mGlu4 Modulator
Valiglurax is a potent, orally active positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4), exhibiting EC50 values of 64.6 nM and 197 nM for human mGlu4/Gqi5 and rat mGlu4 GIRK, respectively. It effectively penetrates the central nervous system (CNS), making it a valuable tool for studying pharmacological pathways involved in neurological disorders. Valiglurax is particularly relevant for research focused on Parkinson's disease, enabling investigations into potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1976050-09-5 |
| Applications | mGlu4 Modulator |
| Formula | C16H10F3N5 |
| Molecular Weight | 329.28 |
| Synonyms | VU0652957; VU2957 |
| SMILES | FC(C1=NC=CC2=C1C=CC(NC3=NNC4=NC=CC=C43)=C2)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.