Fig. 1 · Structure
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Valsartan methyl ester
Angiotensin II Antagonist
Valsartan methyl ester, a methyl ester derivative of Valsartan, serves as a selective angiotensin II type 1 (AT1) receptor antagonist. It exhibits significant antihypertensive and cardioprotective properties by competitively inhibiting the interaction of angiotensin II with AT1 receptors, thereby reducing vasoconstriction, sodium retention, and myocardial hypertrophy signaling. This compound has demonstrated efficacy in lowering systolic blood pressure in L-NAME-induced hypertensive models. Valsartan methyl ester is valuable for research into arterial hypertension, hypertensive heart disease, and heart failure.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 137863-17-3 |
| Applications | Angiotensin II Antagonist |
| Formula | C25H31N5O3 |
| Molecular Weight | 449.55 |
| Synonyms | CGP 48933 methyl ester |
| SMILES | COC([C@H](C(C)C)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.