Vanzacaftor

Catalog No.: A66452
CFTR Modulator
Vanzacaftor is a novel CFTR modulator that acts as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It enhances the proper processing and trafficking of CFTR, thereby promoting increased chloride ion transport in combination with Tezacaftor and Deutivacaftor. This combination has shown efficacy in improving lung function and alleviating respiratory symptoms in cystic fibrosis patients, making it a valuable tool for research aimed at understanding and treating cystic fibrosis-related conditions.
Grouped product items
Size Price Stock Qty
1mg
$155.00
In stock
5mg
$295.00
In stock
10mg
$450.00
In stock
25mg
$660.00
In stock
50mg
$975.00
In stock
100mg
$1,465.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVanzacaftor is a novel CFTR modulator that acts as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It enhances the proper processing and trafficking of CFTR, thereby promoting increased chloride ion transport in combination with Tezacaftor and Deutivacaftor. This combination has shown efficacy in improving lung function and alleviating respiratory symptoms in cystic fibrosis patients, making it a valuable tool for research aimed at understanding and treating cystic fibrosis-related conditions.
Product Information
Catalog NumA66452
FormulaC32H39N7O4S
Molecular Weight617.76
CAS Number2374124-49-7
SMILESCC(C)(C[C@@](CCC/N=C1NC(S(=O)(N2)=O)=CC=C\1)([H])C3)N3C4=NC(N(C=C5)N=C5OCCC6C7(CC7)C68CC8)=CC=C4C2=O
SynonymsVX-121
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