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Varenicline-15N3 Hydrochloride

Isotope-Labeled Compounds

Varenicline-15N3 Hydrochloride is the nitrogen-15 labeled isotope of Varenicline hydrochloride, a known partial agonist of the α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) with an IC50 value of 250 nM. It targets nicotine dependence by mitigating the direct agonistic effects of nicotine while providing moderate stimulation of nAChR. Additionally, Varenicline exhibits partial agonist activity at α6β2 nAChR and full agonism at another subset of this receptor. This isotope-labeled compound is valuable for pharmacokinetic studies and research into nicotine addiction and smoking cessation therapies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1244134-80-2
Applications	Isotope-Labeled Compounds
Formula	C₁₃H₁₄Cl₁₅N₃
Molecular Weight	250.70
Synonyms	CP 526555-15N3 Hydrochloride
SMILES	C1(C2CC3C[15NH]C2)=C3C=C([15N]=CC=[15N]4)C4=C1.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.