Fig. 1 · Structure
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Variegatic acid
PKCβ1 Inhibitor
Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM, derived from basidiomycete fungi. It effectively inhibits antigen-induced and calcium ionophore-induced β-hexosaminidase release, with IC₅₀ values of 10.4 μM and 22.2 μM, respectively, as well as TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM). By suppressing the enzymatic activity of calcium-activated PKCβ1, variegatic acid also facilitates the generation of hydroxyl radicals through its action on Fe(III), making it valuable for research focused on biological degradation and allergic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 20988-30-1 |
| Applications | PKCβ1 Inhibitor |
| Formula | C18H12O9 |
| Molecular Weight | 372.29 |
| SMILES | C(\C(O)=O)(=C/1\C(O)=C(C(=O)O1)C2=CC(O)=C(O)C=C2)/C3=CC(O)=C(O)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.