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VARS1-IN-1

VARS1 Inhibitor

VARS1-IN-1 is a potent inhibitor of valyl-tRNA synthetase (VARS1), exhibiting a Kd of 0.213 μM. This compound effectively suppresses VARS1's tRNA aminoacylation activity, leading to a reduction in charged valine tRNAs and a decrease in overall protein synthesis rates. In preclinical studies, VARS1-IN-1 demonstrated the ability to inhibit aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models, making it a valuable tool for prostate cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	428830-84-6
Applications	VARS1 Inhibitor
Formula	C₂₁H₁₅N₅OS
Molecular Weight	385.44
SMILES	CC1=CC=C(C2=NN(C(/C3=C/C4=CNC5=C4C=CC=C5)=N)C(S2)=NC3=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.