Fig. 1 · Structure
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Vepafestinib
RET Inhibitor
Vepafestinib is a selective, orally active RET inhibitor that demonstrates a potent inhibitory effect with an IC50 value of 0.33 nM. By inhibiting the phosphorylation of RET and its downstream signaling pathways, Vepafestinib effectively blocks tumor cell proliferation and induces cell cycle arrest and apoptosis. This compound is valuable for research on RET-driven malignancies, including non-small cell lung cancer and thyroid cancer, among other applications in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2129515-96-2 |
| Applications | RET Inhibitor |
| Formula | C26H30N6O3 |
| Molecular Weight | 474.55 |
| Synonyms | TAS0953/HM06 |
| SMILES | O=C(C1=C(C#CCN2CCOCC2)N(C3(C)CC3)C4=NC=NC(N)=C41)NC5=CC=C(COC)C=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.