Fig. 1 · Structure
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Verrucarin A
Protein Synthesis Inhibitor
Verrucarin A is a Type D macrocyclic mycotoxin that acts as a potent inhibitor of protein synthesis. Derived from the pathogenic fungus Myrothecium verrucaria, Verrucarin A demonstrates significant anti-leukemic activity by inducing apoptosis and activating caspase cascades in leukemia cell lines. Moreover, it modulates inflammatory signaling in macrophages by increasing p38 MAPK phosphorylation while decreasing ERK/Akt phosphorylation, leading to cell cycle dysregulation through the induction of p21 and p53. This compound is valuable for research into cancer biology and inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3148-09-2 |
| Applications | Protein Synthesis Inhibitor |
| Formula | C27H34O9 |
| Molecular Weight | 502.55 |
| Synonyms | Muconomycin A |
| SMILES | C[C@@]12[C@]3(CO3)[C@@]4([H])C[C@@]1([H])OC(/C=C/C=C/C(OCC[C@@H](C)[C@H](O)C(OC[C@]25[C@](C=C(C)CC5)([H])O4)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.