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Verticilide

Ryanodine-Binding Inhibitor

Verticilide is a ryanodine-binding inhibitor that specifically targets ryanodine receptors. It effectively inhibits ryanodine binding in the cockroach with an IC50 value of 4.2 μM, demonstrating significant specificity as compared to mouse ryanodine receptors, where inhibition is weak, with an IC50 of 53.9 μM. This compound is useful for studying calcium signaling pathways and the physiological roles of ryanodine receptors in various biological systems.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	693778-57-3
Applications	Ryanodine-Binding Inhibitor
Formula	C₄₄H₇₆N₄O₁₂
Molecular Weight	853.09
SMILES	CCCCC[C@@H](OC([C@@H](N(C([C@H](OC([C@@H](N(C1=O)C)C)=O)CCCCC)=O)C)C)=O)C(N([C@H](C(O[C@@H](C(N([C@H](C(O[C@@H]1CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.