Fig. 1 · Structure
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VGSCs-IN-1
VGSCs Inhibitor
VGSCs-IN-1 is a selective inhibitor of human voltage-gated sodium channels (VGSCs), specifically demonstrating significant blocking activity against the Nav1.4 subtype. This 2-piperazine derivative of Riluzole has a pKa of 7.6 and a cLog P of 2.4, indicating favorable pharmacological properties. VGSCs-IN-1 is a valuable tool for investigating cell excitability disorders and related pathways in scientific research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1204296-79-6 |
| Applications | VGSCs Inhibitor |
| Formula | C12H12F3N3OS |
| Molecular Weight | 303.30 |
| SMILES | FC(F)(F)OC1=CC2=C(C=C1)N=C(N3CCNCC3)S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.