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VHL Ligand 38

VHL Inhibitor

VHL Ligand 38 is a competitive inhibitor of the E3 ubiquitin-protein ligase VHL, exhibiting IC50 values of 4.1 μM and 7.0 μM in 1% and 10% DMSO, respectively. This compound features a hydroxyproline residue and an isoxazolylacetamide moiety, making it a valuable tool for research. VHL Ligand 38 effectively disrupts the interaction between VHL and a fluorescent peptide derived from HIF1α, facilitating studies on hypoxia-related signaling pathways and protein degradation mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1360616-29-0
Applications	VHL Inhibitor
Formula	C₂₁H₂₂N₄O₅
Molecular Weight	410.42
SMILES	O=C([C@H]1N(C(CC2=CC(C)=NO2)=O)C[C@H](O)C1)NCC3=CC=C(C4=CN=CO4)C=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.