Fig. 1 · Structure
Documents & Downloads
Vicadrostat
Aldosterone Synthase Inhibitor
Vicadrostat is an orally active inhibitor of aldosterone synthase, exhibiting IC50 values of 19 nM, 16 nM, and 18 μM against human, cynomolgus monkey, and rat aldosterone synthase, respectively. This compound demonstrates a favorable in vivo IC50 of 25 nM for inhibiting aldosterone synthesis, providing high selectivity for cortisol synthase. Vicadrostat effectively reduces aldosterone production and decreases plasma aldosterone levels, making it a valuable reagent for research in chronic kidney disease, heart failure, and hypertension.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1868065-21-7 |
| Applications | Aldosterone Synthase Inhibitor |
| Formula | C15H12ClN3O3 |
| Molecular Weight | 317.73 |
| Synonyms | BI 690517 |
| SMILES | O=C1C2=C(C[C@@](C)(O1)CO)N=CN2C3=CC(Cl)=C(C=C3)C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.