Fig. 1 · Structure
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VISTA-IN-2
VISTA Inhibitor
VISTA-IN-2 is a potent inhibitor of the V-domain Ig suppressor of T-cell activation (VISTA). This compound promotes the degradation of VISTA through an autophagic mechanism, effectively alleviating VISTA-mediated immunosuppression and bolstering the antitumor activity of immune cells. In preclinical studies utilizing a CT26 mouse model, VISTA-IN-2 has been shown to activate antitumor immunity and significantly inhibit tumor growth, making it a valuable tool for cancer research and immunotherapy development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2614183-36-5 |
| Applications | VISTA Inhibitor |
| Formula | C23H23N3O |
| Molecular Weight | 357.45 |
| SMILES | CC1=C2NC(C3=CC(CNCCO)=CC=C3)=NC2=CC=C1C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.