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VL-422

Cationic Lipid

VL-422 is an ionizable cationic lipid designed for the delivery of CRISPR/Cas9 components, including single-guide RNA (sgRNA) and Cas9 mRNA. It facilitates in vitro and in vivo gene editing by effectively transporting these nucleic acids to target cells. In preclinical studies using cynomolgus monkeys, VL-422 encapsulating Cas9 mRNA and ANGPTL3-targeting sgRNA demonstrated the capability to induce deletions of premature stop codons, resulting in reduced LDL, HDL, and cholesterol levels in plasma. This versatile delivery system is instrumental in advancing research on gene editing strategies associated with lipid metabolism disorders.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2765519-47-7
Applications	Cationic Lipid
Formula	C₆₂H₁₁₇NO₁₁
Molecular Weight	1052.59
SMILES	O=C(OCC(COC(CCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)COC(CCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)OCCCN(CC)CC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.