Fig. 1 · Structure
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(−)-Voacangarine
Antitumor Agent
(−)-Voacangarine is an indole alkaloid known for its antitumor activity. It demonstrates significant cytotoxic effects against various cancer cell lines, including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26, with IC50 values ranging from 5 to 20 mg/mL. Additionally, (−)-Voacangarine inhibits the growth of Saccharomyces cerevisiae, affecting both wild-type and repair-deficient mutant strains, making it a valuable tool for cancer research and cellular biology studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 545-84-6 |
| Applications | Antitumor Agent |
| Formula | C22H28N2O4 |
| Molecular Weight | 384.47 |
| SMILES | O=C([C@@]1([C@@]([C@@](C2)([H])[C@@H](O)C)([H])[N@@]3C[C@@]2([H])C1)C4=C(CC3)C5=CC(OC)=CC=C5N4)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.