Fig. 1 · Structure
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Volanesorsen sodium
Antisense Oligonucleotide
Volanesorsen sodium is an antisense oligonucleotide designed to inhibit apolipoprotein CIII (apo-CIII) mRNA, effectively lowering triglyceride levels and enhancing insulin sensitivity. This compound is under investigation for its therapeutic potential in hypertriglyceridemia, familial chylomicronemia syndrome, and type 2 diabetes. Its unique mechanism positions it as a valuable tool for research into lipid metabolism and related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1573402-50-2 |
| Applications | Antisense Oligonucleotide |
| Formula | C230H301N63Na19O125P19S19 |
| Molecular Weight | 7165 (free acid) |
| Synonyms | ISIS 304801 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.