Fig. 1 · Structure
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Volixibat
ASBT Inhibitor
Volixibat is a selective and competitive inhibitor of the apical sodium-dependent bile acid transporter (ASBT). It demonstrates minimal systemic absorption, making it a promising candidate for the treatment of non-alcoholic steatohepatitis (NASH). Research applications for Volixibat include studies on bile acid transport and metabolism, as well as its potential therapeutic effects in liver diseases associated with bile acid dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1025216-57-2 |
| Applications | ASBT Inhibitor |
| Formula | C38H51N3O12S2 |
| Molecular Weight | 805.95 |
| Synonyms | SHP626; LUM002 |
| SMILES | O=C(N[C@H]1[C@@H]([C@H]([C@@H]([C@@H](COS(=O)(O)=O)O1)O)OCC2=CC=CC=C2)O)NC3=CC=CC([C@H](C4=CC(N(C)C)=CC=C45)[C@@H](O)[C@](CC)(CCCC)CS5(=O)=O)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.