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Vonlerizumab

Vonlerizumab is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target TNFRSF4, also known as OX40 or CD134. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, with an estimated molecular weight of 145.22 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended. Vonlerizumab is applicable in research focused on the modulation of immune responses, particularly in the context of cancer immunotherapy and autoimmune diseases.

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Biological Activity

Target & Activity

TNFRSF4/OX40/CD134

Product Details

Manufacturer Adooq Bioscience
CAS Number 1638935-72-4

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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