Vorasidenib

Catalog No.: A16908

IDH1 Inhibitor

Vorasidenib

Vorasidenib Chemical Structure

CAS NO. 1644545-52-7

Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity.

Availability: In stock

Package Price Qty
2 mg
$85.00
5 mg
$135.00
10 mg
$225.00
50 mg
$675.00
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Biological Activity

Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity.
In vitro DMSO 75 mg/mL (180.83 mM)
Water Insoluble
Ethanol 75 mg/mL (180.83 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.11 mL 120.56 mL 241.11 mL
0.5 mM 4.82 mL 24.11 mL 48.22 mL
1 mM 2.41 mL 12.06 mL 24.11 mL
5 mM 0.48 mL 2.41 mL 4.82 mL

*The above data is based on the productmolecular weight 414.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16908
Actions Inhibitor
CAS No. 1644545-52-7
Formula C14H13ClF6N6
M. Wt 414.74
Purity >98%
Synonyms AG-881, AG 881, AG881
SMILES C[[email protected]@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[[email protected]](C)C(F)(F)F)=N1)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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