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IDH1 Inhibitor
In Stock
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| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HT-1080 | IC50 | < 50 nM | Antiproliferative activity against human HT1080 cells after 72 hrs by celltiterglo reagent based assay | [PMID: 29847930] |
| U-87MG ATCC | IC50 | < 50 nM | Antiproliferative activity against human U87MG cells expressing pLVX-IDH2 R140Q mutant after 72 hrs by celltiterglo reagent based assay | [PMID: 29847930] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1644545-52-7 |
| Applications | IDH1 Inhibitor |
| Formula | C14H13ClF6N6 |
| Molecular Weight | 414.74 |
| Synonyms | AG-881 |
| SMILES | C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 75 mg/mL (180.83 mM) |
| Water | Insoluble |
| Ethanol | 75 mg/mL (180.83 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
