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Vortioxetine-d6

Serotonin Transporter Inhibitor

Vortioxetine-d6 is a deuterium-labeled variant of Vortioxetine, primarily acting as a serotonin transporter (SERT) inhibitor with a Ki value of 1.6 nM. Additionally, it functions as an antagonist of the 5-HT3A and 5-HT7 receptors, with Ki values of 3.7 nM and 19 nM, respectively. This compound also exhibits agonist activity at 5-HT1A and partial agonist properties at 5-HT1B receptors, with Ki values of 15 nM and 33 nM. Vortioxetine-d6 is valuable for research into the modulation of serotonergic systems and the study of related psychiatric disorders.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1629684-23-6
Applications	Serotonin Transporter Inhibitor
Formula	C₁₈H₁₆D₆N₂S
Molecular Weight	304.48
Synonyms	Lu AA 21004-d6
SMILES	[2H]C([2H])(C1=CC=C(C(C([2H])([2H])[2H])=C1)SC2=CC=CC=C2N3CCNCC3)[2H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.