Voxelotor (GBT 440) is an orally bioavailable sickle hemoglobin (HbS) polymerization inhibitor.
Product Information
Catalog Num
A20863
Formula
C19H19N3O3
Molecular Weight
337.37
CAS Number
1446321-46-5
SMILES
OC1=CC=CC(OCC2=C(C3=CC=NN3C(C)C)N=CC=C2)=C1C=O
Synonyms
GBT 440, GBT-440, GBT440
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
60 mg/mL (177.84 mM)
Water
Insoluble
Ethanol
60 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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