Fig. 1 · Structure
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VPC-18005
ERG Inhibitor
VPC-18005 is an inhibitor targeting the ERG transcription factor by directly interacting with its ETS domain, leading to disruption of ERG's binding to DNA. This compound effectively inhibits ERG-induced transcription and has demonstrated potent inhibition of luciferase activity. VPC-18005 is valuable for research into the regulatory mechanisms of gene expression mediated by ERG, with potential applications in cancer biology and other ERG-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2242480-48-2 |
| Applications | ERG Inhibitor |
| Formula | C15H17N3O3S |
| Molecular Weight | 319.38 |
| SMILES | O=C(O)CC(S/C(N1)=N\N=C/C2=CC=C(C(C)C)C=C2)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.