Fig. 1 · Structure
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VPC-70619
N-Myc Inhibitor
VPC-70619 is a potent inhibitor of the N-Myc transcription factor, effectively blocking the interaction between the N-Myc-Max heterocomplex and DNA E-box elements. This compound demonstrates significant inhibitory effects on N-Myc-dependent cell lines and can partially reverse resistance to paclitaxel by downregulating MYCN expression. VPC-70619 is a valuable tool for cancer research, particularly in studies focused on neuroblastoma and thyroid cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2361742-30-3 |
| Applications | N-Myc Inhibitor |
| Formula | C16H8ClF3N4O |
| Molecular Weight | 364.71 |
| SMILES | N#CC1=CC(C(F)(F)F)=C(C=C1)NNC(C2=CC=C(C(Cl)=C2)C#N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.