Fig. 1 · Structure
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VRK1/CK1-IN-1
VRK1/CK1 Family Inhibitor
VRK1/CK1-IN-1 is a potent dual inhibitor targeting the VRK1 and CK1 family kinases, demonstrating a Ki of 37.9 nM for human VRK1, 8.3 nM for human CK1δ, and 7.8 nM for human CK1ε. This compound exhibits minimal activity against VRK2, allowing for selective inhibition. VRK1/CK1-IN-1 is particularly useful in research focused on p53-deficient tumors, providing insights into signaling pathways and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3050772-20-5 |
| Applications | VRK1/CK1 Family Inhibitor |
| Formula | C19H18F2N6O3 |
| Molecular Weight | 416.38 |
| SMILES | O=C1N(CC2=CC(C)=NO2)C3=CN=C(NC4=CC(F)=C(O)C(F)=C4)N=C3N(C)[C@H]1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.