Fig. 1 · Structure
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VRT-534
Chemical Chaperone
VRT-534 is a chemical chaperone that targets connexin 26 (Cx26). This compound demonstrates dose-responsive binding to both wild-type and mutant Cx26, specifically with EC50 values of 19 μM and 5 μM for recombinant Cx26 and the K188N mutation, respectively. VRT-534 is utilized in research addressing hearing impairment, providing insights into the molecular mechanisms underlying connexin-related auditory dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 926664-32-6 |
| Applications | Chemical Chaperone |
| Formula | C25H24ClN3O4S |
| Molecular Weight | 497.99 |
| SMILES | O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.