Fig. 1 · Structure
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VT103
TEAD1 Palmitoylation Inhibitor
VT103 is a selective inhibitor of TEAD1 palmitoylation, effectively disrupting the auto-palmitoylation of TEAD and the interaction between YAP/TAZ and TEAD. This compound inhibits YAP/TAZ-mediated gene transcription, highlighting its role in modulating the Hippo signaling pathway. VT103 is particularly useful for research in cancer biology, providing insights into tumorigenesis associated with aberrant TEAD signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2290608-13-6 |
| Applications | TEAD1 Palmitoylation Inhibitor |
| Formula | C18H17F3N4O2S |
| Molecular Weight | 410.41 |
| SMILES | O=S(C1=CC=C(NC2=CC=C(C(F)(F)F)C=C2)C(C3=CN(C)C=N3)=C1)(NC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.