Fig. 1 · Structure
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VTP50469 fumarate
Menin-MLL Interaction Inhibitor
VTP50469 fumarate is a potent and highly selective inhibitor of the Menin-MLL interaction, with a Ki value of 104 pM. This compound exhibits significant anti-leukemic activity, making it a valuable tool for research into targeted therapies for leukemia and related hematological malignancies. Its oral bioavailability further enhances its utility in preclinical studies investigating Menin-MLL pathway modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2169919-29-1 |
| Applications | Menin-MLL Interaction Inhibitor |
| Formula | C32H47FN6O4S.3/2C4H4O4 |
| Molecular Weight | 804.93 |
| Synonyms | SNDX-50469 fumarate |
| SMILES | O=C(O)/C=C/C(O)=O.O=C(N(C(C)C)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@H](NS(=O)(C)=O)CC5)CC4)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.