Fig. 1 · Structure
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VU-1545
mGluR5 PAM
VU-1545 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with a Ki of 156 nM and an EC50 of 9.6 nM. This compound enhances mGluR5 activity, offering potential insights into synaptic transmission and plasticity. VU-1545 is valuable in research focused on neurological disorders, cognition, and mood regulation, making it a useful tool for studying the role of mGluR5 in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 890764-63-3 |
| Applications | mGluR5 PAM |
| Formula | C22H15FN4O3 |
| Molecular Weight | 402.38 |
| SMILES | O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3F)C4=CC=C([N+]([O-])=O)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.