VU-29 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R), demonstrating an EC50 of 9 nM and a Ki of 244 nM for rat mGluR5. This compound exhibits remarkable selectivity for mGlu5R compared to other mGluR subtypes, with EC50 values of 557 nM and 1.5 μM for rat mGluR1 and rat mGluR2, respectively, and 154 nM for human mGluR4. VU-29 is valuable for research exploring mGlu5R modulation in neurological studies, potentially aiding in the understanding of mechanisms underlying various neuropsychiatric disorders.
VU-29 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5R), demonstrating an EC50 of 9 nM and a Ki of 244 nM for rat mGluR5. This compound exhibits remarkable selectivity for mGlu5R compared to other mGluR subtypes, with EC50 values of 557 nM and 1.5 μM for rat mGluR1 and rat mGluR2, respectively, and 154 nM for human mGluR4. VU-29 is valuable for research exploring mGlu5R modulation in neurological studies, potentially aiding in the understanding of mechanisms underlying various neuropsychiatric disorders.
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