VU0029251 is a partial antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), exhibiting a binding affinity with a Ki value of 1.07 μM. It effectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing rat mGluR5, with an IC50 of 1.7 μM. This compound is valuable for research into mGluR5-related signaling pathways and potential therapeutic applications in neurological disorders.
VU0029251 is a partial antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), exhibiting a binding affinity with a Ki value of 1.07 μM. It effectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing rat mGluR5, with an IC50 of 1.7 μM. This compound is valuable for research into mGluR5-related signaling pathways and potential therapeutic applications in neurological disorders.
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