Fig. 1 · Structure
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VU0029251
mGluR5 Partial Antagonist
VU0029251 is a partial antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), exhibiting a binding affinity with a Ki value of 1.07 μM. It effectively inhibits glutamate-induced calcium mobilization in HEK293 cells expressing rat mGluR5, with an IC50 of 1.7 μM. This compound is valuable for research into mGluR5-related signaling pathways and potential therapeutic applications in neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 330819-85-7 |
| Applications | mGluR5 Partial Antagonist |
| Formula | C10H11N3S2 |
| Molecular Weight | 237.34 |
| SMILES | NC1=C2C(SC3=C2CCC3)=NC(SC)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.