VU0071063 is a selective activator of the Kir6.2/SUR1 potassium channel complex, exhibiting an EC50 of 7.44 μM. This compound is primarily used to study the physiological roles of Kir6.2/SUR1 in pancreatic and neuronal tissues. VU0071063 promotes hyperpolarization of β-cell membrane potential, effectively inhibiting insulin secretion. The compound’s chemotype demonstrates a pronounced structure-activity relationship, making it a valuable tool for exploring insulin signaling and regulatory mechanisms in cellular physiology.
VU0071063 is a selective activator of the Kir6.2/SUR1 potassium channel complex, exhibiting an EC50 of 7.44 μM. This compound is primarily used to study the physiological roles of Kir6.2/SUR1 in pancreatic and neuronal tissues. VU0071063 promotes hyperpolarization of β-cell membrane potential, effectively inhibiting insulin secretion. The compound’s chemotype demonstrates a pronounced structure-activity relationship, making it a valuable tool for exploring insulin signaling and regulatory mechanisms in cellular physiology.
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