Fig. 1 · Structure
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VU0071063
Kir6.2/SUR1 Activator
VU0071063 is a selective activator of the Kir6.2/SUR1 potassium channel complex, exhibiting an EC50 of 7.44 μM. This compound is primarily used to study the physiological roles of Kir6.2/SUR1 in pancreatic and neuronal tissues. VU0071063 promotes hyperpolarization of β-cell membrane potential, effectively inhibiting insulin secretion. The compound’s chemotype demonstrates a pronounced structure-activity relationship, making it a valuable tool for exploring insulin signaling and regulatory mechanisms in cellular physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 333415-38-6 |
| Applications | Kir6.2/SUR1 Activator |
| Formula | C18H22N4O2 |
| Molecular Weight | 326.39 |
| SMILES | O=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.