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VU0092273

mGlu5 PAM

VU0092273 is a potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5), exhibiting an EC50 value of 0.27 μM. This compound enhances mGlu5 receptor activity by binding to the MPEP site, thereby increasing the responsiveness of the receptor to glutamate. VU0092273 is utilized in research applications investigating synaptic plasticity, neuroprotection, and potential therapeutic strategies for neuropsychiatric disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	393110-43-5
Applications	mGlu5 PAM
Formula	C₂₀H₁₉NO₂
Molecular Weight	305.37
SMILES	O=C(N1CCC(O)CC1)C2=CC=C(C#CC3=CC=CC=C3)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.