Fig. 1 · Structure
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VU0240382
mGluR Modulator
VU0240382 is a modulator of metabotropic glutamate receptor subtype 5 (mGluR5), exhibiting dual mechanisms governed by its allosteric agonist activity. When functioning as an allosteric agonist, VU0240382 effectively activates mGluR5 receptors in cell line studies; however, it does not demonstrate agonist activity in natural biological systems. Its efficacy parallels that of mGluR5 modulators lacking allosteric agonist properties in animal models, making it a valuable tool for researching psychiatric disorders and neurological diseases where mGluR5 is implicated.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1092550-36-1 |
| Applications | mGluR Modulator |
| Formula | C17H13NO |
| Molecular Weight | 247.29 |
| SMILES | O=C1NCCC2=C1C=CC(C#CC3=CC=CC=C3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.