Fig. 1 · Structure
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VU0285683
mGluR5 PAM
VU0285683 is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGluR5). It demonstrates anxiolytic-like effects in rodent models of anxiety, providing valuable insights into the modulation of glutamatergic signaling. This compound is primarily utilized in biological research focused on anxiety disorders and the pharmacological mechanisms underlying mGluR5 modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 327056-22-4 |
| Applications | mGluR5 PAM |
| Formula | C14H7FN4O |
| Molecular Weight | 266.23 |
| SMILES | N#CC1=CC(C2=NC(C3=NC=CC=C3)=NO2)=CC(F)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.