Fig. 1 · Structure

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VU0357017

M1R Agonist

VU0357017 is a potent and selective allosteric agonist of the M1 muscarinic acetylcholine receptor, displaying an EC50 of 477 nM. It exhibits strong selectivity for the M1 receptor with no activity observed at M2-M5 subtypes at concentrations up to 30 μM. This compound is valuable for research focused on neurodegenerative disorders such as Alzheimer’s disease and psychiatric conditions like schizophrenia.

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Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 1135681-23-0
Applications M1R Agonist
Formula C18H27N3O3
Molecular Weight 333.43
Synonyms CID-25010775 free base
SMILES
O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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