Fig. 1 · Structure
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VU0366248
mGlu5 Negative Allosteric Modulator
VU0366248 is a negative allosteric modulator of the metabotropic glutamate receptor type 5 (mGlu5). This compound inhibits mGlu5 receptor signaling, offering potential therapeutic applications in disorders associated with glutamate dysregulation, such as anxiety, depression, and schizophrenia. Researchers can utilize VU0366248 to investigate the functional role of mGlu5 in synaptic plasticity and to explore its implications in neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1243310-20-4 |
| Applications | mGlu5 Negative Allosteric Modulator |
| Formula | C14H7ClF2N2O |
| Molecular Weight | 292.67 |
| SMILES | O=C(C1=CC(F)=CC(C#N)=C1)NC2=CC=CC(Cl)=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.