Fig. 1 · Structure
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VU0409106
mGlu5 NAM
VU0409106 is a potent and selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5), exhibiting an IC50 of 24 nM. This compound demonstrates anxiolytic effects in rat models, influenced by concentration-dependent mechanisms. Additionally, VU0409106 effectively crosses the blood-brain barrier, making it a valuable tool for investigating mGlu5-related neurological conditions and potential therapeutic strategies in anxiety disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1276617-62-9 |
| Applications | mGlu5 NAM |
| Formula | C15H11FN4O2S |
| Molecular Weight | 330.34 |
| SMILES | CC1=CSC(NC(C2=CC(F)=CC(OC3=CN=CN=C3)=C2)=O)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.