Fig. 1 · Structure
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VU041
Mosquito Kir1 Channels Inhibitor
VU041 is a potent inhibitor of the inward rectifier potassium 1 (Kir1) channels in Anopheles gambiae and Aedes aegypti, exhibiting submicromolar affinity with IC50 values of 2.5 μM and 1.7 μM, respectively. This compound also demonstrates moderate inhibition of mammalian Kir2.1 (IC50 of 12.7 μM) while showing minimal effects on other mammalian Kir channels. VU041 has been shown to disrupt Malpighian tubule function, making it a valuable tool for research into mosquito physiology and potential pest control strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 332943-64-3 |
| Applications | Mosquito Kir1 Channels Inhibitor |
| Formula | C19H20F3N3O |
| Molecular Weight | 363.38 |
| SMILES | FC(C1=NN(CC(N2CCCC3=C2C=CC=C3)=O)C4=C1CCCC4)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.