Fig. 1 · Structure
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VU0410425
mGlu1 Negative Allosteric Modulator
VU0410425 is a negative allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1). It demonstrates potent inhibitory activity in rat mGlu1 with an IC50 value of 140 nM. This compound is suitable for investigating the role of mGlu1 in various central nervous system disorders, providing valuable insights for therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1341167-72-3 |
| Applications | mGlu1 Negative Allosteric Modulator |
| Formula | C19H16ClN3O3 |
| Molecular Weight | 369.80 |
| SMILES | O=C(C1=NC=CC=C1)NC2=CC=C(N3C(C4C(C)(C)C4C3=O)=O)C(Cl)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.