Fig. 1 · Structure
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VU0422288
mGluRs Positive Allosteric Modulator
VU0422288 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs). It demonstrates inhibitory activity with EC50 values of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively, as established in calcium mobilization assays. This compound has potential applications in addressing deficits in contextual fear memory, social recognition, and apneas in models of Rett syndrome.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1630936-95-6 |
| Applications | mGluRs Positive Allosteric Modulator |
| Formula | C17H11Cl2N3O2 |
| Molecular Weight | 360.19 |
| Synonyms | ML396 |
| SMILES | ClC(C=C(NC(C1=CC=CC=N1)=O)C=C2)=C2OC3=CC=C(Cl)C=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.