VU0463841 is a selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5), demonstrating a potent IC50 of 13 nM. This compound exhibits specificity, showing no significant activity against mGlu1-4 and mGlu7-8. VU0463841 is valuable for research into the mechanisms underlying cocaine addiction and other neuropsychiatric disorders.
VU0463841 is a selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5), demonstrating a potent IC50 of 13 nM. This compound exhibits specificity, showing no significant activity against mGlu1-4 and mGlu7-8. VU0463841 is valuable for research into the mechanisms underlying cocaine addiction and other neuropsychiatric disorders.
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