Fig. 1 · Structure
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VU0463841
mGlu5 NAM
VU0463841 is a selective negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5), demonstrating a potent IC50 of 13 nM. This compound exhibits specificity, showing no significant activity against mGlu1-4 and mGlu7-8. VU0463841 is valuable for research into the mechanisms underlying cocaine addiction and other neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1439095-16-5 |
| Applications | mGlu5 NAM |
| Formula | C13H8ClFN4O |
| Molecular Weight | 290.68 |
| SMILES | O=C(NC1=NC=C(C=C1)Cl)NC2=CC(F)=CC(C#N)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.