VU0469650 is a potent and selective negative allosteric modulator of the mGlu1 receptor, exhibiting an IC50 of 99 nM. This compound demonstrates significant brain penetration, making it a valuable tool for investigating the role of mGlu1 in various neurological conditions. Its primary applications include studying glutamatergic signaling pathways and their implications in disorders such as anxiety and depression.
VU0469650 is a potent and selective negative allosteric modulator of the mGlu1 receptor, exhibiting an IC50 of 99 nM. This compound demonstrates significant brain penetration, making it a valuable tool for investigating the role of mGlu1 in various neurological conditions. Its primary applications include studying glutamatergic signaling pathways and their implications in disorders such as anxiety and depression.
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