Fig. 1 · Structure
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VU0469650
mGlu1 Modulator
VU0469650 is a potent and selective negative allosteric modulator of the mGlu1 receptor, exhibiting an IC50 of 99 nM. This compound demonstrates significant brain penetration, making it a valuable tool for investigating the role of mGlu1 in various neurological conditions. Its primary applications include studying glutamatergic signaling pathways and their implications in disorders such as anxiety and depression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1443748-47-7 |
| Applications | mGlu1 Modulator |
| Formula | C22H28N4O |
| Molecular Weight | 364.48 |
| SMILES | O=C(N1[C@@H](CN(C2=C(N=CC=C2)C#N)CC1)C)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.