Fig. 1 · Structure
Documents & Downloads
VU0477886
mGluR Activator
VU0477886 is a positive allosteric modulator of metabotropic glutamate receptor subtype 4 (mGlu4), demonstrating potent activation with an EC50 value of 95 nM and achieving 89% of maximal glutamate response. This compound exhibits favorable pharmacokinetic properties, with a brain-to-plasma distribution ratio (Kp) of 1.3, making it a suitable candidate for neurological research. VU0477886 has shown significant therapeutic effects in preclinical models of Parkinson's disease, highlighting its potential for the treatment of movement disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1926222-30-1 |
| Applications | mGluR Activator |
| Formula | C20H13ClN4O3 |
| Molecular Weight | 392.80 |
| SMILES | O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.