Fig. 1 · Structure
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VU0483605
mGlu1 Modulator
VU0483605 is a selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1). It demonstrates strong PAM activity with EC50 values of 390 nM in human and 356 nM in rat, indicating effective modulation across species. This compound is valuable for investigating the role of mGlu1 in neurological disorders and in studying synaptic plasticity and cognitive functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1623101-11-0 |
| Applications | mGlu1 Modulator |
| Formula | C20H10Cl3N3O3 |
| Molecular Weight | 446.67 |
| SMILES | O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.