Fig. 1 · Structure
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VU0486321
mGluR Agonist
VU0486321 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGluR1), exhibiting significant potency and selectivity for this target. The compound demonstrates a favorable drug metabolism and pharmacokinetics (DMPK) profile along with central nervous system (CNS) permeability. VU0486321 is primarily applicable in research related to neurological disorders and the modulation of synaptic activity, making it a valuable tool for exploring mGluR1-related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1816301-67-3 |
| Applications | mGluR Agonist |
| Formula | C20H12ClFN2O4 |
| Molecular Weight | 398.77 |
| SMILES | FC1=C2C(C(N(C2=O)C3=CC=C(C=C3Cl)NC(C4=C(C=CO4)C)=O)=O)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.