Fig. 1 · Structure
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VU0514009
CMKLR1 Antagonist
VU0514009 is a competitive antagonist of chemokine-like receptor 1 (CMKLR1), exhibiting an EC50 of 2 nM. This compound effectively inhibits chemerin-9-induced arrestin recruitment and receptor internalization, leading to a significant reduction in Ca2+ flux response in HEK293 cells. VU0514009 holds potential for research applications in the fields of inflammatory diseases and metabolic syndrome.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 932973-77-8 |
| Applications | CMKLR1 Antagonist |
| Formula | C21H20ClN3O5S2 |
| Molecular Weight | 493.98 |
| SMILES | O=C1C(S(C2=CC=C(C(Cl)=C2)C)(=O)=O)=CNC(SCC(NC3=CC(C)=CC=C3OC)=O)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.