Fig. 1 · Structure
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VU534
NAPE-PLD Activator
VU534 is a potent activator of N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD), exhibiting an EC50 of 0.30 μM. This compound also functions as a dual inhibitor of fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH) with IC50 values of 1.2 μM. VU534 enhances efferocytosis in a NAPE-PLD dependent manner, making it a valuable tool for investigating mechanisms related to cardiometabolic diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 923509-20-0 |
| Applications | NAPE-PLD Activator |
| Formula | C21H22FN3O3S2 |
| Molecular Weight | 447.55 |
| SMILES | CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.