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VU6001221

CHT Inhibitor

VU6001221 is a choline transporter (CHT) inhibitor with a reported IC50 of 270 nM, demonstrating its ability to cross the blood-brain barrier. This compound enhances extracellular choline levels, thereby increasing the activation of synaptic α7 nicotinic acetylcholine receptors. Additionally, VU6001221 has been shown to reduce potassium-induced acetylcholine levels in the prefrontal cortex, making it a valuable tool for studying cholinergic signaling and its implications in neurological research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2002495-17-0
Applications	CHT Inhibitor
Formula	C₂₀H₂₆ClN₃O₃
Molecular Weight	391.89
SMILES	O=C(NCC1=CC(C(C)C)=NO1)C2=CC=C(Cl)C(OC3CCN(C)CC3)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.