Fig. 1 · Structure
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VU6001966
mGlu2 Negative Allosteric Modulator
VU6001966 is a potent negative allosteric modulator of the metabotropic glutamate receptor 2 (mGlu2), exhibiting an IC50 of 78 nM, while demonstrating selectivity for mGlu2 over mGlu3 with an IC50 of >30 µM. This compound effectively crosses the blood-brain barrier, making it a valuable tool for neurological research. VU6001966 can also be utilized as a positron emission tomography (PET) tracer for studying mGlu2 dynamics, contributing to the understanding of glutamatergic signaling in various cognitive processes and neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2009052-76-8 |
| Applications | mGlu2 Negative Allosteric Modulator |
| Formula | C17H15FN4O2 |
| Molecular Weight | 326.33 |
| SMILES | O=C(C1=NC=C(OCC2=NN(C)C=C2)C(C3=CC=C(F)C=C3)=C1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.