Fig. 1 · Structure
Documents & Downloads
VU6004909
mGlu1 Positive Allosteric Modulator
VU6004909 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), effectively crossing the blood-brain barrier. With EC50 values of 25.7 nM for human mGlu1 and 31 nM for rat mGlu1, it demonstrates significant modulation of receptor activity. VU6004909 has been shown to reduce dopamine release in the dorsolateral striatum in vivo, indicating potential applications in the treatment of psychotic disorders.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1860797-76-7 |
| Applications | mGlu1 Positive Allosteric Modulator |
| Formula | C21H15FN2O4 |
| Molecular Weight | 378.35 |
| SMILES | O=C(C1=C(C)C=CO1)NC2=CC=C(N3C(C4=CC=C(C)C=C4C3=O)=O)C=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.