VU6004909 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), effectively crossing the blood-brain barrier. With EC50 values of 25.7 nM for human mGlu1 and 31 nM for rat mGlu1, it demonstrates significant modulation of receptor activity. VU6004909 has been shown to reduce dopamine release in the dorsolateral striatum in vivo, indicating potential applications in the treatment of psychotic disorders.
VU6004909 is a positive allosteric modulator of the metabotropic glutamate receptor 1 (mGlu1), effectively crossing the blood-brain barrier. With EC50 values of 25.7 nM for human mGlu1 and 31 nM for rat mGlu1, it demonstrates significant modulation of receptor activity. VU6004909 has been shown to reduce dopamine release in the dorsolateral striatum in vivo, indicating potential applications in the treatment of psychotic disorders.
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